Julian F B Mercer Selected Research

Menkes Kinky Hair Syndrome (Menkes Disease)

4/2016	Copper dyshomoeostasis in Parkinson's disease: implications for pathogenesis and indications for novel therapeutics.
5/2014	Metabolism and functions of copper in brain.
3/2010	Missense mutations in the copper transporter gene ATP7A cause X-linked distal hereditary motor neuropathy.
4/2008	ATP7A transgenic and nontransgenic mice are resistant to high copper exposure.
5/2007	Copper-transporting P-type ATPase, ATP7A, confers multidrug resistance and its expression is related to resistance to SN-38 in clinical colon cancer.
1/2007	Purification and membrane reconstitution of catalytically active Menkes copper-transporting P-type ATPase (MNK; ATP7A).
5/2006	Alteration of copper physiology in mice overexpressing the human Menkes protein ATP7A.
1/2003	Molecular and cellular aspects of copper transport in developing mammals.
11/2002	Copper-regulated trafficking of the Menkes disease copper ATPase is associated with formation of a phosphorylated catalytic intermediate.
11/2002	Correction of the copper transport defect of Menkes patient fibroblasts by expression of two forms of the sheep Wilson ATPase.

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Julian F B Mercer Research Topics

Disease

13	Hepatolenticular Degeneration (Wilson's Disease) 04/2016 - 04/2002
11	Menkes Kinky Hair Syndrome (Menkes Disease) 04/2016 - 04/2002
4	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 04/2016 - 04/2002
4	Neurodegenerative Diseases (Neurodegenerative Disease) 04/2016 - 07/2007
4	Alzheimer Disease (Alzheimer's Disease) 04/2016 - 04/2002
2	Parkinson Disease (Parkinson's Disease) 04/2016 - 04/2014
2	Prion Diseases (Transmissible Spongiform Encephalopathies) 04/2016 - 04/2002
1	Central Nervous System Diseases (CNS Diseases) 04/2016
1	Huntington Disease (Huntington's Disease) 04/2016
1	Lewy Body Disease (Lewy Body Dementia) 04/2014
1	Metabolic Diseases (Metabolic Disease) 11/2013
1	Nervous System Diseases (Neurological Disorders) 01/2013
1	Dementia (Dementias) 04/2012
1	Muscular Diseases (Myopathy) 04/2012
1	Occipital horn syndrome 03/2010
1	Amyloid Plaque 05/2008
1	Neuroblastoma 05/2008
1	Neoplasms (Cancer) 05/2007
1	Colonic Neoplasms (Colon Cancer) 05/2007
1	Hemolysis 10/2006
1	Hepatocellular Carcinoma (Hepatoma) 02/2006
1	Liver Diseases (Liver Disease) 01/2004

Drug/Important Bio-Agent (IBA)

21	CopperIBA 04/2016 - 04/2002
9	Proteins (Proteins, Gene)FDA Link 06/2014 - 11/2002
7	P-type ATPasesIBA 03/2010 - 11/2002
2	ClusterinIBA 01/2012 - 03/2011
2	Copper-Transporting ATPasesIBA 03/2007 - 04/2002
2	Adenosine Triphosphatases (ATPase)IBA 06/2004 - 11/2002
1	Trace Elements (Biometals)IBA 04/2016
1	copper (II) diacetyl- di(N(4)- methylthiosemicarbazone)IBA 06/2014
1	Superoxide Dismutase-1IBA 06/2014
1	Oxidants (Oxidizing Agents)IBA 11/2013
1	Copper Transport ProteinsIBA 11/2013
1	UbiquitinIBA 04/2012
1	Drinking WaterIBA 10/2007
1	Irinotecan (Camptosar)FDA LinkGeneric 05/2007
1	Vincristine (Oncovin)FDA LinkGeneric 05/2007
1	Paclitaxel (Taxol)FDA LinkGeneric 05/2007
1	Etoposide (VP 16)FDA LinkGeneric 05/2007
1	Pharmaceutical PreparationsIBA 05/2007
1	Doxorubicin (Adriamycin)FDA LinkGeneric 05/2007
1	Antineoplastic Agents (Antineoplastics)IBA 05/2007
1	ZincIBA 10/2006
1	IronIBA 10/2006
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 11/2002

Therapy/Procedure

2	Therapeutics 04/2016 - 01/2004
1	Synchrotrons 04/2014
1	Stem Cell Transplantation 01/2004
1	Transplantation 01/2004